Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Identifieur interne : 006143 ( Main/Exploration ); précédent : 006142; suivant : 006144Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Auteurs : Gunter Schumann [Royaume-Uni] ; Lachlan J. Coin [Royaume-Uni] ; Anbarasu Lourdusamy [Royaume-Uni] ; Pimphen Charoen [Royaume-Uni, Thaïlande] ; Karen H. Berger [États-Unis] ; David Stacey [Royaume-Uni] ; Sylvane Desrivières [Royaume-Uni] ; Fazil A. Aliev [États-Unis] ; Anokhi A. Khan [Royaume-Uni] ; Najaf Amin [Pays-Bas] ; Yurii S. Aulchenko [Pays-Bas] ; Georgy Bakalkin [Suède] ; Stephan J. Bakker [Pays-Bas] ; Beverley Balkau [France] ; Joline W. Beulens [Pays-Bas] ; Ainhoa Bilbao [Allemagne] ; Rudolf A. De Boer [Pays-Bas] ; Delphine Beury ; Michiel L. Bots [Pays-Bas] ; Elemi J. Breetvelt [Pays-Bas] ; Stéphane Cauchi ; Christine Cavalcanti-Proença ; John C. Chambers [Royaume-Uni] ; Toni-Kim Clarke [Royaume-Uni] ; Norbert Dahmen [Allemagne] ; Eco J. De Geus [États-Unis] ; Danielle Dick [États-Unis] ; Francesca Ducci [Royaume-Uni] ; Alanna Easton [Royaume-Uni] ; Howard J. Edenberg [États-Unis] ; T Nu Esko [Estonie] ; Alberto Fernández-Medarde [Espagne] ; Tatiana Foroud [États-Unis] ; Nelson B. Freimer [États-Unis] ; Jean-Antoine Girault [France] ; Diederick E. Grobbee [Allemagne] ; Simonetta Guarrera [Italie] ; Daniel F. Gudbjartsson [Islande] ; Anna-Liisa Hartikainen [Finlande] ; Andrew C. Heath [États-Unis] ; Victor Hesselbrock [États-Unis] ; Albert Hofman [Pays-Bas] ; Jouke-Jan Hottenga [Pays-Bas] ; Matti K. Isohanni [Finlande] ; Jaakko Kaprio [Finlande] ; Kay-Tee Khaw [Royaume-Uni] ; Brigitte Kuehnel [Allemagne] ; Jaana Laitinen [Finlande] ; Stéphane Lobbens ; Jian'An Luan ; Massimo Mangino [Royaume-Uni] ; Matthieu Maroteaux [France] ; Giuseppe Matullo [Italie] ; Mark I. Mccarthy [Royaume-Uni] ; Christian Mueller [Royaume-Uni, Allemagne] ; Gerjan Navis [Pays-Bas] ; Mattijs E. Numans [Pays-Bas] ; Alejandro Nú Ez [Espagne] ; Dale R. Nyholt [Australie] ; Charlotte N. Onland-Moret [Pays-Bas] ; Ben A. Oostra [Suède] ; Paul F. O'Reilly [Royaume-Uni] ; Miklos Palkovits [Hongrie] ; Brenda W. Penninx [Pays-Bas] ; Silvia Polidoro [Italie] ; Anneli Pouta [Finlande] ; Inga Prokopenko [Royaume-Uni] ; Fulvio Ricceri [Italie] ; Eugenio Santos [Espagne] ; Johannes H. Smit [Pays-Bas] ; Nicole Soranzo [Royaume-Uni] ; Kijoung Song [États-Unis] ; Ulla Sovio [Royaume-Uni] ; Michael Stumvoll [Allemagne] ; Ida Surakk [Finlande] ; Thorgeir E. Thorgeirsson [Islande] ; Unnur Thorsteinsdottir [Islande] ; Claire Troakes [Royaume-Uni] ; Thorarinn Tyrfingsson [Islande] ; Anke Tönjes [Allemagne] ; Cuno S. Uiterwaal [Pays-Bas] ; Andre G. Uitterlinden [Pays-Bas] ; Pim Van Der Harst [Pays-Bas] ; Yvonne T. Van Der Schouw [Pays-Bas] ; Oliver Staehlin [Allemagne] ; Nicole Vogelzangs [Pays-Bas] ; Peter Vollenweider [Suisse] ; Gerard Waeber [Suisse] ; Nicholas J. Wareham ; Dawn M. Waterworth [États-Unis] ; John B. Whitfield [Australie] ; Erich H. Wichmann [Allemagne] ; Gonneke Willemsen [Pays-Bas] ; Jacqueline C. Witteman [Pays-Bas] ; Xin Yuan [États-Unis] ; Guangju Zhai [Royaume-Uni] ; Jing H. Zhao ; Weihua Zhang [Royaume-Uni] ; Nicholas G. Martin [Australie] ; Andres Metspalu [Estonie] ; Angela Doering [Allemagne] ; James Scott [Royaume-Uni] ; Tim D. Spector [Royaume-Uni] ; Ruth J. Loos ; Dorret I. Boomsma [Pays-Bas] ; Vincent Mooser [États-Unis] ; Leena Peltonen [Royaume-Uni] ; Kari Stefansson [Islande] ; Cornelia M. Van Duijn [Pays-Bas] ; Paolo Vineis [Royaume-Uni, Italie] ; Wolfgang H. Sommer [Allemagne] ; Jaspal S. Kooner [Royaume-Uni] ; Rainer Spanagel [Allemagne] ; Ulrike A. Heberlein [États-Unis] ; Marjo-Riitta Jarvelin [Royaume-Uni, Finlande] ; Paul Elliott [Royaume-Uni]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2011.
Abstract
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in
Url:
DOI: 10.1073/pnas.1017288108
PubMed: 21471458
PubMed Central: 3084048
Affiliations:
- Allemagne, Australie, Espagne, Estonie, Finlande, France, Hongrie, Islande, Italie, Pays-Bas, Royaume-Uni, Suisse, Suède, Thaïlande, États-Unis
- Californie, Connecticut, Indiana, Missouri (État), Pennsylvanie, Virginie
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Coin</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lourdusamy, Anbarasu" sort="Lourdusamy, Anbarasu" uniqKey="Lourdusamy A" first="Anbarasu" last="Lourdusamy">Anbarasu Lourdusamy</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Tropical Hygiene, Faculty of Tropical Medicine,<institution>Mahidol University</institution>, Bangkok 10400,<country>Thailand</country>;</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Imperial College Healthcare NHS Trust Comprehensive Biomedical Research Centre</institution>, London W2 1PG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation></author><author><name sortKey="Berger, Karen H" sort="Berger, Karen H" uniqKey="Berger K" first="Karen H." last="Berger">Karen H. Berger</name><affiliation wicri:level="2"><nlm:aff id="aff5">Ernest Gallo Clinic and Research Center,<institution>University of California at San Francisco</institution>, Emeryville, CA 94608;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>, Emeryville</wicri:cityArea></affiliation></author><author><name sortKey="Stacey, David" sort="Stacey, David" uniqKey="Stacey D" first="David" last="Stacey">David Stacey</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Desrivieres, Sylvane" sort="Desrivieres, Sylvane" uniqKey="Desrivieres S" first="Sylvane" last="Desrivières">Sylvane Desrivières</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aliev, Fazil A" sort="Aliev, Fazil A" uniqKey="Aliev F" first="Fazil A." last="Aliev">Fazil A. Aliev</name><affiliation wicri:level="2"><nlm:aff id="aff6"><institution>Virginia Commonwealth University</institution>, Richmond, VA 23284;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>, Richmond</wicri:cityArea></affiliation></author><author><name sortKey="Khan, Anokhi A" sort="Khan, Anokhi A" uniqKey="Khan A" first="Anokhi A." last="Khan">Anokhi A. Khan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:aff id="aff7">Genetic Epidemiology Unit, Department of Epidemiology and Clinical Genetics,<institution>Erasmus University Medical Centre</institution>, Rotterdam 3000CA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><affiliation wicri:level="1"><nlm:aff id="aff7">Genetic Epidemiology Unit, Department of Epidemiology and Clinical Genetics,<institution>Erasmus University Medical Centre</institution>, Rotterdam 3000CA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bakalkin, Georgy" sort="Bakalkin, Georgy" uniqKey="Bakalkin G" first="Georgy" last="Bakalkin">Georgy Bakalkin</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Pharmaceutical Biosciences,<institution>Uppsala University</institution>, Uppsala 751 24,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bakker, Stephan J" sort="Bakker, Stephan J" uniqKey="Bakker S" first="Stephan J." last="Bakker">Stephan J. Bakker</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Internal Medicine, University Medical Center Groningen,<institution>University of Groningen</institution>, Groningen 9700 RB,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Institut National de la Santé et de la Recherche Médicale U780</institution>, 75654 Paris,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>University Paris-Sud</institution>, F-91405 Orsay,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beulens, Joline W" sort="Beulens, Joline W" uniqKey="Beulens J" first="Joline W." last="Beulens">Joline W. Beulens</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bilbao, Ainhoa" sort="Bilbao, Ainhoa" uniqKey="Bilbao A" first="Ainhoa" last="Bilbao">Ainhoa Bilbao</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Psychopharmacology,<institution>Central Institute of Mental Health</institution>, 68159 Mannheim,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A." last="De Boer">Rudolf A. De Boer</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, Groningen 9700 RB,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beury, Delphine" sort="Beury, Delphine" uniqKey="Beury D" first="Delphine" last="Beury">Delphine Beury</name><affiliation><nlm:aff id="aff15">Department of Genomics and Molecular Physiology of Metabolic Diseases, Centre National de la Recherche Scientifique-Unité Mixte de Recherche-8090,<institution>Institute of Biology of Lille, BP 44759021 Lille, France</institution>;</nlm:aff></affiliation></author><author><name sortKey="Bots, Michiel L" sort="Bots, Michiel L" uniqKey="Bots M" first="Michiel L." last="Bots">Michiel L. Bots</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Breetvelt, Elemi J" sort="Breetvelt, Elemi J" uniqKey="Breetvelt E" first="Elemi J." last="Breetvelt">Elemi J. Breetvelt</name><affiliation wicri:level="1"><nlm:aff id="aff16">Department of Psychiatry,<institution>Universitair Medisch Centrum Utrecht</institution>, Utrecht 3584 CX,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stéphane" last="Cauchi">Stéphane Cauchi</name><affiliation><nlm:aff id="aff15">Department of Genomics and Molecular Physiology of Metabolic Diseases, Centre National de la Recherche Scientifique-Unité Mixte de Recherche-8090,<institution>Institute of Biology of Lille, BP 44759021 Lille, France</institution>;</nlm:aff></affiliation></author><author><name sortKey="Cavalcanti Proenca, Christine" sort="Cavalcanti Proenca, Christine" uniqKey="Cavalcanti Proenca C" first="Christine" last="Cavalcanti-Proença">Christine Cavalcanti-Proença</name><affiliation><nlm:aff id="aff15">Department of Genomics and Molecular Physiology of Metabolic Diseases, Centre National de la Recherche Scientifique-Unité Mixte de Recherche-8090,<institution>Institute of Biology of Lille, BP 44759021 Lille, France</institution>;</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C." last="Chambers">John C. Chambers</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Clarke, Toni Kim" sort="Clarke, Toni Kim" uniqKey="Clarke T" first="Toni-Kim" last="Clarke">Toni-Kim Clarke</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dahmen, Norbert" sort="Dahmen, Norbert" uniqKey="Dahmen N" first="Norbert" last="Dahmen">Norbert Dahmen</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Psychiatry and Psychotherapy,<institution>University of Mainz</institution>, 55131 Mainz,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Geus, Eco J" sort="De Geus, Eco J" uniqKey="De Geus E" first="Eco J." last="De Geus">Eco J. De Geus</name><affiliation wicri:level="2"><nlm:aff id="aff18">Indiana University,<institution>School of Medicine</institution>, Indianapolis, IN 46202-3082;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>, Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Dick, Danielle" sort="Dick, Danielle" uniqKey="Dick D" first="Danielle" last="Dick">Danielle Dick</name><affiliation wicri:level="2"><nlm:aff id="aff6"><institution>Virginia Commonwealth University</institution>, Richmond, VA 23284;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>, Richmond</wicri:cityArea></affiliation></author><author><name sortKey="Ducci, Francesca" sort="Ducci, Francesca" uniqKey="Ducci F" first="Francesca" last="Ducci">Francesca Ducci</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Alanna" sort="Easton, Alanna" uniqKey="Easton A" first="Alanna" last="Easton">Alanna Easton</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Edenberg, Howard J" sort="Edenberg, Howard J" uniqKey="Edenberg H" first="Howard J." last="Edenberg">Howard J. Edenberg</name><affiliation wicri:level="2"><nlm:aff id="aff18">Indiana University,<institution>School of Medicine</institution>, Indianapolis, IN 46202-3082;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>, Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Biotechnology, Institute of Molecular and Cell Biology, Faculty of Science and Technology,<institution>University of Tartu</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Estonian Genome Project of University of Tartu</institution>, Tartu 50410,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Estonian Biocentre</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fernandez Medarde, Alberto" sort="Fernandez Medarde, Alberto" uniqKey="Fernandez Medarde A" first="Alberto" last="Fernández-Medarde">Alberto Fernández-Medarde</name><affiliation wicri:level="1"><nlm:aff id="aff22">Comision de Investigaciones Cientificas de la Provincia de Buenos Aires-Instituto de Biología Molecular y Celular del Cáncer de Salamanca,<institution>University of Salamanca–Consejo Superior de Investigaciones Cientificas (Spain)</institution>, 37007 Salamanca,<country>Spain</country>;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="2"><nlm:aff id="aff18">Indiana University,<institution>School of Medicine</institution>, Indianapolis, IN 46202-3082;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>, Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B." last="Freimer">Nelson B. Freimer</name><affiliation wicri:level="2"><nlm:aff id="aff23">University of California Los Angeles Center for Neurobehavioural Genetics,<institution>Semel Institute for Neuroscience and Human Behavior,</institution> Los Angeles, CA 90095;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Girault, Jean Antoine" sort="Girault, Jean Antoine" uniqKey="Girault J" first="Jean-Antoine" last="Girault">Jean-Antoine Girault</name><affiliation wicri:level="1"><nlm:aff id="aff24">Institut du Fer à Moulin, Institut National de la Santé et de la Recherche Médicale,<institution>Université Pierre et Marie Curie</institution>, 75005 Paris,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E." last="Grobbee">Diederick E. Grobbee</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Psychopharmacology,<institution>Central Institute of Mental Health</institution>, 68159 Mannheim,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guarrera, Simonetta" sort="Guarrera, Simonetta" uniqKey="Guarrera S" first="Simonetta" last="Guarrera">Simonetta Guarrera</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Institute for Scientific Interchange</institution>, Turin 10133,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gudbjartsson, Daniel F" sort="Gudbjartsson, Daniel F" uniqKey="Gudbjartsson D" first="Daniel F." last="Gudbjartsson">Daniel F. Gudbjartsson</name><affiliation wicri:level="1"><nlm:aff id="aff26">deCODE genetics, Faculty of Medicine,<institution>Reykjavik and University of Iceland</institution>, Reykjavik IS 101,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="aff27">Institute of Clinical Medicine,<institution>University of Oulu</institution>, FI-90014, Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation wicri:level="2"><nlm:aff id="aff28">Department of Psychiatry,<institution>Washington University School of Medicine</institution>, St. Louis, MO 63110;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Hesselbrock, Victor" sort="Hesselbrock, Victor" uniqKey="Hesselbrock V" first="Victor" last="Hesselbrock">Victor Hesselbrock</name><affiliation wicri:level="2"><nlm:aff id="aff29"><institution>University of Connecticut</institution>, Farmington, CT 06030;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>, Farmington</wicri:cityArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="aff7">Genetic Epidemiology Unit, Department of Epidemiology and Clinical Genetics,<institution>Erasmus University Medical Centre</institution>, Rotterdam 3000CA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Biological Psychology,<institution>Vrije Universiteit and VU Medical Center</institution>, Amsterdam 1081 HV,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Isohanni, Matti K" sort="Isohanni, Matti K" uniqKey="Isohanni M" first="Matti K." last="Isohanni">Matti K. Isohanni</name><affiliation wicri:level="1"><nlm:aff id="aff27">Institute of Clinical Medicine,<institution>University of Oulu</institution>, FI-90014, Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="1"><nlm:aff id="aff31">Department of Public Health,<institution>University of Helsinki</institution>, FI-00014, Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Mental Health and Substance Abuse Services,<institution>National Institute for Health and Welfare</institution>, FI-00271, Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Institute for Molecular Medicine</institution>, FI-00014, Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="aff34">Clinical Gerontology, Department of Public Health and Primary Care, School of Clinical Medicine,<institution>University of Cambridge</institution>, Cambridge CB2 0SP,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kuehnel, Brigitte" sort="Kuehnel, Brigitte" uniqKey="Kuehnel B" first="Brigitte" last="Kuehnel">Brigitte Kuehnel</name><affiliation wicri:level="1"><nlm:aff id="aff35">Institute of Epidemiology, Helmholtz Zentrum,<institution>German Research Center for Environmental Health</institution>, D-85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Finnish Institute of Occupational Health</institution>, FI-90220, Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lobbens, Stephane" sort="Lobbens, Stephane" uniqKey="Lobbens S" first="Stéphane" last="Lobbens">Stéphane Lobbens</name><affiliation><nlm:aff id="aff15">Department of Genomics and Molecular Physiology of Metabolic Diseases, Centre National de la Recherche Scientifique-Unité Mixte de Recherche-8090,<institution>Institute of Biology of Lille, BP 44759021 Lille, France</institution>;</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation><nlm:aff id="aff37"><institution>Medical Research Council Epidemiology Unit–Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom;</institution></nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation wicri:level="1"><nlm:aff id="aff38">Department of Twin Research and Genetic Epidemiology,<institution>King's College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maroteaux, Matthieu" sort="Maroteaux, Matthieu" uniqKey="Maroteaux M" first="Matthieu" last="Maroteaux">Matthieu Maroteaux</name><affiliation wicri:level="1"><nlm:aff id="aff24">Institut du Fer à Moulin, Institut National de la Santé et de la Recherche Médicale,<institution>Université Pierre et Marie Curie</institution>, 75005 Paris,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Matullo, Giuseppe" sort="Matullo, Giuseppe" uniqKey="Matullo G" first="Giuseppe" last="Matullo">Giuseppe Matullo</name><affiliation wicri:level="1"><nlm:aff id="aff39">Institute for Scientific Information Foundation and Department of Genetics, Biology and Biochemistry,<institution>University of Turin</institution>, Turin 10126,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation wicri:level="1"><nlm:aff id="aff40">Oxford Centre for Diabetes, Endocrinology and Metabolism,<institution>University of Oxford</institution>, Oxford OX3 7LJ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mueller, Christian" sort="Mueller, Christian" uniqKey="Mueller C" first="Christian" last="Mueller">Christian Mueller</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff41">Department of Psychiatry and Psychotherapy,<institution>University of Erlangen-Nuernberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Internal Medicine, University Medical Center Groningen,<institution>University of Groningen</institution>, Groningen 9700 RB,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Numans, Mattijs E" sort="Numans, Mattijs E" uniqKey="Numans M" first="Mattijs E." last="Numans">Mattijs E. Numans</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nu Ez, Alejandro" sort="Nu Ez, Alejandro" uniqKey="Nu Ez A" first="Alejandro" last="Nú Ez">Alejandro Nú Ez</name><affiliation wicri:level="1"><nlm:aff id="aff22">Comision de Investigaciones Cientificas de la Provincia de Buenos Aires-Instituto de Biología Molecular y Celular del Cáncer de Salamanca,<institution>University of Salamanca–Consejo Superior de Investigaciones Cientificas (Spain)</institution>, 37007 Salamanca,<country>Spain</country>;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R." last="Nyholt">Dale R. Nyholt</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Queensland Institute of Medical Research</institution>, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Onland Moret, Charlotte N" sort="Onland Moret, Charlotte N" uniqKey="Onland Moret C" first="Charlotte N." last="Onland-Moret">Charlotte N. Onland-Moret</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff43">Complex Genetics Section, Department of Medical Genetics–Divisie Biomedische Genetica,<institution>University Medical Center</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Pharmaceutical Biosciences,<institution>Uppsala University</institution>, Uppsala 751 24,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F." last="O'Reilly">Paul F. O'Reilly</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Palkovits, Miklos" sort="Palkovits, Miklos" uniqKey="Palkovits M" first="Miklos" last="Palkovits">Miklos Palkovits</name><affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Semmelweiss University</institution>, H-1094, Budapest,<country>Hungary</country>;</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation wicri:level="1"><nlm:aff id="aff45">EMGO Institute for Health and Care Research, Department of Psychiatry,<institution>VU University Medical Center</institution>, Amsterdam 1081 BT,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff46"><institution>University Medical Center</institution>, Groningen 9700 RB,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff47"><institution>Leiden University Medical Center</institution>, Leiden 2333 ZA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polidoro, Silvia" sort="Polidoro, Silvia" uniqKey="Polidoro S" first="Silvia" last="Polidoro">Silvia Polidoro</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Institute for Scientific Interchange</institution>, Turin 10133,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation wicri:level="1"><nlm:aff id="aff48"><institution>National Institute for Health and Welfare</institution>, FI-90101, Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="1"><nlm:aff id="aff40">Oxford Centre for Diabetes, Endocrinology and Metabolism,<institution>University of Oxford</institution>, Oxford OX3 7LJ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff49">Wellcome Trust Centre for Human Genetics,<institution>University of Oxford</institution>, Oxford OX3 7BN,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ricceri, Fulvio" sort="Ricceri, Fulvio" uniqKey="Ricceri F" first="Fulvio" last="Ricceri">Fulvio Ricceri</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Institute for Scientific Interchange</institution>, Turin 10133,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Santos, Eugenio" sort="Santos, Eugenio" uniqKey="Santos E" first="Eugenio" last="Santos">Eugenio Santos</name><affiliation wicri:level="1"><nlm:aff id="aff22">Comision de Investigaciones Cientificas de la Provincia de Buenos Aires-Instituto de Biología Molecular y Celular del Cáncer de Salamanca,<institution>University of Salamanca–Consejo Superior de Investigaciones Cientificas (Spain)</institution>, 37007 Salamanca,<country>Spain</country>;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><affiliation wicri:level="1"><nlm:aff id="aff45">EMGO Institute for Health and Care Research, Department of Psychiatry,<institution>VU University Medical Center</institution>, Amsterdam 1081 BT,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="aff38">Department of Twin Research and Genetic Epidemiology,<institution>King's College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff50">Wellcome Trust Sanger Institute,<institution>Wellcome Trust Genome Campus</institution>, Hinxton CB10 1SA,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Song, Kijoung" sort="Song, Kijoung" uniqKey="Song K" first="Kijoung" last="Song">Kijoung Song</name><affiliation wicri:level="2"><nlm:aff id="aff51">Genetics Division, Research and Development,<institution>GlaxoSmithKline</institution>, King of Prussia, PA 19406;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation wicri:level="1"><nlm:aff id="aff52">Department of Medicine,<institution>University of Leipzig</institution>, 04103 Leipzig,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff53">Leipzig Research Centre for Modern Diseases (LIFE),<institution>University of Leipzig</institution>, 04103 Leipzig,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Surakk, Ida" sort="Surakk, Ida" uniqKey="Surakk I" first="Ida" last="Surakk">Ida Surakk</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Institute for Molecular Medicine</institution>, FI-00014, Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff54">Public Health Genomics,<institution>National Institute for Health and Welfare</institution>, FI-00271, Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thorgeirsson, Thorgeir E" sort="Thorgeirsson, Thorgeir E" uniqKey="Thorgeirsson T" first="Thorgeir E." last="Thorgeirsson">Thorgeir E. Thorgeirsson</name><affiliation wicri:level="1"><nlm:aff id="aff26">deCODE genetics, Faculty of Medicine,<institution>Reykjavik and University of Iceland</institution>, Reykjavik IS 101,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="aff26">deCODE genetics, Faculty of Medicine,<institution>Reykjavik and University of Iceland</institution>, Reykjavik IS 101,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Troakes, Claire" sort="Troakes, Claire" uniqKey="Troakes C" first="Claire" last="Troakes">Claire Troakes</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tyrfingsson, Thorarinn" sort="Tyrfingsson, Thorarinn" uniqKey="Tyrfingsson T" first="Thorarinn" last="Tyrfingsson">Thorarinn Tyrfingsson</name><affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Vogur Samtök áhugafólks um áfengis Addiction Treatment Center</institution>, Reykjavik 112,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation wicri:level="1"><nlm:aff id="aff52">Department of Medicine,<institution>University of Leipzig</institution>, 04103 Leipzig,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff56">University of Leipzig,<institution>Coordination Centre for Clinical Trials</institution>, 04317 Leipzig,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uiterwaal, Cuno S" sort="Uiterwaal, Cuno S" uniqKey="Uiterwaal C" first="Cuno S." last="Uiterwaal">Cuno S. Uiterwaal</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="aff57">Department of Internal Medicine,<institution>Erasmus University Medical Center</institution>, Rotterdam 3015 CE,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, Groningen 9700 RB,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T." last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Staehlin, Oliver" sort="Staehlin, Oliver" uniqKey="Staehlin O" first="Oliver" last="Staehlin">Oliver Staehlin</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Psychopharmacology,<institution>Central Institute of Mental Health</institution>, 68159 Mannheim,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vogelzangs, Nicole" sort="Vogelzangs, Nicole" uniqKey="Vogelzangs N" first="Nicole" last="Vogelzangs">Nicole Vogelzangs</name><affiliation wicri:level="1"><nlm:aff id="aff45">EMGO Institute for Health and Care Research, Department of Psychiatry,<institution>VU University Medical Center</institution>, Amsterdam 1081 BT,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="1"><nlm:aff id="aff58">Department of Medicine,<institution>Centre Hospitalier Universitaire Vaudois University Hospital</institution>, CH-1011 Lausanne,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gerard" last="Waeber">Gerard Waeber</name><affiliation wicri:level="1"><nlm:aff id="aff58">Department of Medicine,<institution>Centre Hospitalier Universitaire Vaudois University Hospital</institution>, CH-1011 Lausanne,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="aff37"><institution>Medical Research Council Epidemiology Unit–Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom;</institution></nlm:aff></affiliation></author><author><name sortKey="Waterworth, Dawn M" sort="Waterworth, Dawn M" uniqKey="Waterworth D" first="Dawn M." last="Waterworth">Dawn M. Waterworth</name><affiliation wicri:level="2"><nlm:aff id="aff51">Genetics Division, Research and Development,<institution>GlaxoSmithKline</institution>, King of Prussia, PA 19406;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Queensland Institute of Medical Research</institution>, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wichmann, Erich H" sort="Wichmann, Erich H" uniqKey="Wichmann E" first="Erich H." last="Wichmann">Erich H. Wichmann</name><affiliation wicri:level="1"><nlm:aff id="aff35">Institute of Epidemiology, Helmholtz Zentrum,<institution>German Research Center for Environmental Health</institution>, D-85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff59">Institute of Medical Informatics, Biometry and Epidemiology,<institution>Ludwig Maximilians University</institution>, D-80336 Munich,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff60"><institution>Klinikum Grosshadern</institution>, D-81377 Munich,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Biological Psychology,<institution>Vrije Universiteit and VU Medical Center</institution>, Amsterdam 1081 HV,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Witteman, Jacqueline C" sort="Witteman, Jacqueline C" uniqKey="Witteman J" first="Jacqueline C." last="Witteman">Jacqueline C. Witteman</name><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Epidemiology,<institution>Erasmus University Medical Center</institution>, Rotterdam 3015 GE,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yuan, Xin" sort="Yuan, Xin" uniqKey="Yuan X" first="Xin" last="Yuan">Xin Yuan</name><affiliation wicri:level="2"><nlm:aff id="aff51">Genetics Division, Research and Development,<institution>GlaxoSmithKline</institution>, King of Prussia, PA 19406;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Zhai, Guangju" sort="Zhai, Guangju" uniqKey="Zhai G" first="Guangju" last="Zhai">Guangju Zhai</name><affiliation wicri:level="1"><nlm:aff id="aff38">Department of Twin Research and Genetic Epidemiology,<institution>King's College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jing H" sort="Zhao, Jing H" uniqKey="Zhao J" first="Jing H." last="Zhao">Jing H. Zhao</name><affiliation><nlm:aff id="aff37"><institution>Medical Research Council Epidemiology Unit–Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom;</institution></nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Queensland Institute of Medical Research</institution>, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Biotechnology, Institute of Molecular and Cell Biology, Faculty of Science and Technology,<institution>University of Tartu</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Estonian Genome Project of University of Tartu</institution>, Tartu 50410,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Estonian Biocentre</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Doering, Angela" sort="Doering, Angela" uniqKey="Doering A" first="Angela" last="Doering">Angela Doering</name><affiliation wicri:level="1"><nlm:aff id="aff35">Institute of Epidemiology, Helmholtz Zentrum,<institution>German Research Center for Environmental Health</institution>, D-85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="aff38">Department of Twin Research and Genetic Epidemiology,<institution>King's College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loos, Ruth J" sort="Loos, Ruth J" uniqKey="Loos R" first="Ruth J." last="Loos">Ruth J. Loos</name><affiliation><nlm:aff id="aff37"><institution>Medical Research Council Epidemiology Unit–Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom;</institution></nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Biological Psychology,<institution>Vrije Universiteit and VU Medical Center</institution>, Amsterdam 1081 HV,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mooser, Vincent" sort="Mooser, Vincent" uniqKey="Mooser V" first="Vincent" last="Mooser">Vincent Mooser</name><affiliation wicri:level="2"><nlm:aff id="aff51">Genetics Division, Research and Development,<institution>GlaxoSmithKline</institution>, King of Prussia, PA 19406;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation wicri:level="1"><nlm:aff id="aff50">Wellcome Trust Sanger Institute,<institution>Wellcome Trust Genome Campus</institution>, Hinxton CB10 1SA,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="aff62">Institute for Molecular Medicine Finland (FIMM), Nordic European Molecular Biology Laboratory Partnership for Molecular Medicine, Biomedicum Helsinki 2U,<institution>University of Helsinki and National Institute for Health and Welfare, FI-00014, Helsinki, Finland</institution>;</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="aff26">deCODE genetics, Faculty of Medicine,<institution>Reykjavik and University of Iceland</institution>, Reykjavik IS 101,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="aff7">Genetic Epidemiology Unit, Department of Epidemiology and Clinical Genetics,<institution>Erasmus University Medical Centre</institution>, Rotterdam 3000CA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Institute for Scientific Interchange</institution>, Turin 10133,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sommer, Wolfgang H" sort="Sommer, Wolfgang H" uniqKey="Sommer W" first="Wolfgang H." last="Sommer">Wolfgang H. Sommer</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Psychopharmacology,<institution>Central Institute of Mental Health</institution>, 68159 Mannheim,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation wicri:level="1"><nlm:aff id="aff63">Faculty of Medicine, National Heart and Lung Institute, Cardiovascular Science, Hammersmith Hospital, Hammersmith Campus,<institution>Imperial College</institution> London, London W12 0NN,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spanagel, Rainer" sort="Spanagel, Rainer" uniqKey="Spanagel R" first="Rainer" last="Spanagel">Rainer Spanagel</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Psychopharmacology,<institution>Central Institute of Mental Health</institution>, 68159 Mannheim,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heberlein, Ulrike A" sort="Heberlein, Ulrike A" uniqKey="Heberlein U" first="Ulrike A." last="Heberlein">Ulrike A. Heberlein</name><affiliation wicri:level="2"><nlm:aff id="aff5">Ernest Gallo Clinic and Research Center,<institution>University of California at San Francisco</institution>, Emeryville, CA 94608;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>, Emeryville</wicri:cityArea></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff48"><institution>National Institute for Health and Welfare</institution>, FI-90101, Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="aff64">Institute of Health Sciences,<institution>University of Oulu, FI-90014, Oulu, Finland</institution>;</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff65">Biocenter Oulu,<institution>University of Oulu</institution>, FI-90014, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>, FI-90014, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff66">Medical Research Council-Health Protection Agency Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21471458</idno><idno type="pmc">3084048</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084048</idno><idno type="RBID">PMC:3084048</idno><idno type="doi">10.1073/pnas.1017288108</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001B46</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B46</idno><idno type="wicri:Area/Pmc/Curation">001A04</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001A04</idno><idno type="wicri:Area/Pmc/Checkpoint">002305</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002305</idno><idno type="wicri:Area/Ncbi/Merge">000A30</idno><idno type="wicri:Area/Ncbi/Curation">000A30</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A30</idno><idno type="wicri:doubleKey">0027-8424:2011:Schumann G:genome:wide:association</idno><idno type="wicri:Area/Main/Merge">006501</idno><idno type="wicri:Area/Main/Curation">006143</idno><idno type="wicri:Area/Main/Exploration">006143</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association and genetic functional studies identify <italic>autism susceptibility candidate 2</italic> gene (<italic>AUTS2</italic>) in the regulation of alcohol consumption</title><author><name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coin, Lachlan J" sort="Coin, Lachlan J" uniqKey="Coin L" first="Lachlan J." last="Coin">Lachlan J. Coin</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lourdusamy, Anbarasu" sort="Lourdusamy, Anbarasu" uniqKey="Lourdusamy A" first="Anbarasu" last="Lourdusamy">Anbarasu Lourdusamy</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Tropical Hygiene, Faculty of Tropical Medicine,<institution>Mahidol University</institution>, Bangkok 10400,<country>Thailand</country>;</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Imperial College Healthcare NHS Trust Comprehensive Biomedical Research Centre</institution>, London W2 1PG, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation></author><author><name sortKey="Berger, Karen H" sort="Berger, Karen H" uniqKey="Berger K" first="Karen H." last="Berger">Karen H. Berger</name><affiliation wicri:level="2"><nlm:aff id="aff5">Ernest Gallo Clinic and Research Center,<institution>University of California at San Francisco</institution>, Emeryville, CA 94608;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>, Emeryville</wicri:cityArea></affiliation></author><author><name sortKey="Stacey, David" sort="Stacey, David" uniqKey="Stacey D" first="David" last="Stacey">David Stacey</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Desrivieres, Sylvane" sort="Desrivieres, Sylvane" uniqKey="Desrivieres S" first="Sylvane" last="Desrivières">Sylvane Desrivières</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aliev, Fazil A" sort="Aliev, Fazil A" uniqKey="Aliev F" first="Fazil A." last="Aliev">Fazil A. Aliev</name><affiliation wicri:level="2"><nlm:aff id="aff6"><institution>Virginia Commonwealth University</institution>, Richmond, VA 23284;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>, Richmond</wicri:cityArea></affiliation></author><author><name sortKey="Khan, Anokhi A" sort="Khan, Anokhi A" uniqKey="Khan A" first="Anokhi A." last="Khan">Anokhi A. Khan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:aff id="aff7">Genetic Epidemiology Unit, Department of Epidemiology and Clinical Genetics,<institution>Erasmus University Medical Centre</institution>, Rotterdam 3000CA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><affiliation wicri:level="1"><nlm:aff id="aff7">Genetic Epidemiology Unit, Department of Epidemiology and Clinical Genetics,<institution>Erasmus University Medical Centre</institution>, Rotterdam 3000CA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bakalkin, Georgy" sort="Bakalkin, Georgy" uniqKey="Bakalkin G" first="Georgy" last="Bakalkin">Georgy Bakalkin</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Pharmaceutical Biosciences,<institution>Uppsala University</institution>, Uppsala 751 24,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bakker, Stephan J" sort="Bakker, Stephan J" uniqKey="Bakker S" first="Stephan J." last="Bakker">Stephan J. Bakker</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Internal Medicine, University Medical Center Groningen,<institution>University of Groningen</institution>, Groningen 9700 RB,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Institut National de la Santé et de la Recherche Médicale U780</institution>, 75654 Paris,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>University Paris-Sud</institution>, F-91405 Orsay,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beulens, Joline W" sort="Beulens, Joline W" uniqKey="Beulens J" first="Joline W." last="Beulens">Joline W. Beulens</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bilbao, Ainhoa" sort="Bilbao, Ainhoa" uniqKey="Bilbao A" first="Ainhoa" last="Bilbao">Ainhoa Bilbao</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Psychopharmacology,<institution>Central Institute of Mental Health</institution>, 68159 Mannheim,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A." last="De Boer">Rudolf A. De Boer</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, Groningen 9700 RB,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beury, Delphine" sort="Beury, Delphine" uniqKey="Beury D" first="Delphine" last="Beury">Delphine Beury</name><affiliation><nlm:aff id="aff15">Department of Genomics and Molecular Physiology of Metabolic Diseases, Centre National de la Recherche Scientifique-Unité Mixte de Recherche-8090,<institution>Institute of Biology of Lille, BP 44759021 Lille, France</institution>;</nlm:aff></affiliation></author><author><name sortKey="Bots, Michiel L" sort="Bots, Michiel L" uniqKey="Bots M" first="Michiel L." last="Bots">Michiel L. Bots</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Breetvelt, Elemi J" sort="Breetvelt, Elemi J" uniqKey="Breetvelt E" first="Elemi J." last="Breetvelt">Elemi J. Breetvelt</name><affiliation wicri:level="1"><nlm:aff id="aff16">Department of Psychiatry,<institution>Universitair Medisch Centrum Utrecht</institution>, Utrecht 3584 CX,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stéphane" last="Cauchi">Stéphane Cauchi</name><affiliation><nlm:aff id="aff15">Department of Genomics and Molecular Physiology of Metabolic Diseases, Centre National de la Recherche Scientifique-Unité Mixte de Recherche-8090,<institution>Institute of Biology of Lille, BP 44759021 Lille, France</institution>;</nlm:aff></affiliation></author><author><name sortKey="Cavalcanti Proenca, Christine" sort="Cavalcanti Proenca, Christine" uniqKey="Cavalcanti Proenca C" first="Christine" last="Cavalcanti-Proença">Christine Cavalcanti-Proença</name><affiliation><nlm:aff id="aff15">Department of Genomics and Molecular Physiology of Metabolic Diseases, Centre National de la Recherche Scientifique-Unité Mixte de Recherche-8090,<institution>Institute of Biology of Lille, BP 44759021 Lille, France</institution>;</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C." last="Chambers">John C. Chambers</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Clarke, Toni Kim" sort="Clarke, Toni Kim" uniqKey="Clarke T" first="Toni-Kim" last="Clarke">Toni-Kim Clarke</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dahmen, Norbert" sort="Dahmen, Norbert" uniqKey="Dahmen N" first="Norbert" last="Dahmen">Norbert Dahmen</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Psychiatry and Psychotherapy,<institution>University of Mainz</institution>, 55131 Mainz,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Geus, Eco J" sort="De Geus, Eco J" uniqKey="De Geus E" first="Eco J." last="De Geus">Eco J. De Geus</name><affiliation wicri:level="2"><nlm:aff id="aff18">Indiana University,<institution>School of Medicine</institution>, Indianapolis, IN 46202-3082;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>, Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Dick, Danielle" sort="Dick, Danielle" uniqKey="Dick D" first="Danielle" last="Dick">Danielle Dick</name><affiliation wicri:level="2"><nlm:aff id="aff6"><institution>Virginia Commonwealth University</institution>, Richmond, VA 23284;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>, Richmond</wicri:cityArea></affiliation></author><author><name sortKey="Ducci, Francesca" sort="Ducci, Francesca" uniqKey="Ducci F" first="Francesca" last="Ducci">Francesca Ducci</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Alanna" sort="Easton, Alanna" uniqKey="Easton A" first="Alanna" last="Easton">Alanna Easton</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Edenberg, Howard J" sort="Edenberg, Howard J" uniqKey="Edenberg H" first="Howard J." last="Edenberg">Howard J. Edenberg</name><affiliation wicri:level="2"><nlm:aff id="aff18">Indiana University,<institution>School of Medicine</institution>, Indianapolis, IN 46202-3082;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>, Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Biotechnology, Institute of Molecular and Cell Biology, Faculty of Science and Technology,<institution>University of Tartu</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Estonian Genome Project of University of Tartu</institution>, Tartu 50410,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Estonian Biocentre</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fernandez Medarde, Alberto" sort="Fernandez Medarde, Alberto" uniqKey="Fernandez Medarde A" first="Alberto" last="Fernández-Medarde">Alberto Fernández-Medarde</name><affiliation wicri:level="1"><nlm:aff id="aff22">Comision de Investigaciones Cientificas de la Provincia de Buenos Aires-Instituto de Biología Molecular y Celular del Cáncer de Salamanca,<institution>University of Salamanca–Consejo Superior de Investigaciones Cientificas (Spain)</institution>, 37007 Salamanca,<country>Spain</country>;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="2"><nlm:aff id="aff18">Indiana University,<institution>School of Medicine</institution>, Indianapolis, IN 46202-3082;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>, Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B." last="Freimer">Nelson B. Freimer</name><affiliation wicri:level="2"><nlm:aff id="aff23">University of California Los Angeles Center for Neurobehavioural Genetics,<institution>Semel Institute for Neuroscience and Human Behavior,</institution> Los Angeles, CA 90095;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Girault, Jean Antoine" sort="Girault, Jean Antoine" uniqKey="Girault J" first="Jean-Antoine" last="Girault">Jean-Antoine Girault</name><affiliation wicri:level="1"><nlm:aff id="aff24">Institut du Fer à Moulin, Institut National de la Santé et de la Recherche Médicale,<institution>Université Pierre et Marie Curie</institution>, 75005 Paris,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E." last="Grobbee">Diederick E. Grobbee</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Psychopharmacology,<institution>Central Institute of Mental Health</institution>, 68159 Mannheim,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guarrera, Simonetta" sort="Guarrera, Simonetta" uniqKey="Guarrera S" first="Simonetta" last="Guarrera">Simonetta Guarrera</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Institute for Scientific Interchange</institution>, Turin 10133,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gudbjartsson, Daniel F" sort="Gudbjartsson, Daniel F" uniqKey="Gudbjartsson D" first="Daniel F." last="Gudbjartsson">Daniel F. Gudbjartsson</name><affiliation wicri:level="1"><nlm:aff id="aff26">deCODE genetics, Faculty of Medicine,<institution>Reykjavik and University of Iceland</institution>, Reykjavik IS 101,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="aff27">Institute of Clinical Medicine,<institution>University of Oulu</institution>, FI-90014, Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation wicri:level="2"><nlm:aff id="aff28">Department of Psychiatry,<institution>Washington University School of Medicine</institution>, St. Louis, MO 63110;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Hesselbrock, Victor" sort="Hesselbrock, Victor" uniqKey="Hesselbrock V" first="Victor" last="Hesselbrock">Victor Hesselbrock</name><affiliation wicri:level="2"><nlm:aff id="aff29"><institution>University of Connecticut</institution>, Farmington, CT 06030;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>, Farmington</wicri:cityArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="aff7">Genetic Epidemiology Unit, Department of Epidemiology and Clinical Genetics,<institution>Erasmus University Medical Centre</institution>, Rotterdam 3000CA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Biological Psychology,<institution>Vrije Universiteit and VU Medical Center</institution>, Amsterdam 1081 HV,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Isohanni, Matti K" sort="Isohanni, Matti K" uniqKey="Isohanni M" first="Matti K." last="Isohanni">Matti K. Isohanni</name><affiliation wicri:level="1"><nlm:aff id="aff27">Institute of Clinical Medicine,<institution>University of Oulu</institution>, FI-90014, Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="1"><nlm:aff id="aff31">Department of Public Health,<institution>University of Helsinki</institution>, FI-00014, Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Mental Health and Substance Abuse Services,<institution>National Institute for Health and Welfare</institution>, FI-00271, Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Institute for Molecular Medicine</institution>, FI-00014, Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="aff34">Clinical Gerontology, Department of Public Health and Primary Care, School of Clinical Medicine,<institution>University of Cambridge</institution>, Cambridge CB2 0SP,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kuehnel, Brigitte" sort="Kuehnel, Brigitte" uniqKey="Kuehnel B" first="Brigitte" last="Kuehnel">Brigitte Kuehnel</name><affiliation wicri:level="1"><nlm:aff id="aff35">Institute of Epidemiology, Helmholtz Zentrum,<institution>German Research Center for Environmental Health</institution>, D-85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Finnish Institute of Occupational Health</institution>, FI-90220, Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lobbens, Stephane" sort="Lobbens, Stephane" uniqKey="Lobbens S" first="Stéphane" last="Lobbens">Stéphane Lobbens</name><affiliation><nlm:aff id="aff15">Department of Genomics and Molecular Physiology of Metabolic Diseases, Centre National de la Recherche Scientifique-Unité Mixte de Recherche-8090,<institution>Institute of Biology of Lille, BP 44759021 Lille, France</institution>;</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation><nlm:aff id="aff37"><institution>Medical Research Council Epidemiology Unit–Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom;</institution></nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation wicri:level="1"><nlm:aff id="aff38">Department of Twin Research and Genetic Epidemiology,<institution>King's College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maroteaux, Matthieu" sort="Maroteaux, Matthieu" uniqKey="Maroteaux M" first="Matthieu" last="Maroteaux">Matthieu Maroteaux</name><affiliation wicri:level="1"><nlm:aff id="aff24">Institut du Fer à Moulin, Institut National de la Santé et de la Recherche Médicale,<institution>Université Pierre et Marie Curie</institution>, 75005 Paris,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Matullo, Giuseppe" sort="Matullo, Giuseppe" uniqKey="Matullo G" first="Giuseppe" last="Matullo">Giuseppe Matullo</name><affiliation wicri:level="1"><nlm:aff id="aff39">Institute for Scientific Information Foundation and Department of Genetics, Biology and Biochemistry,<institution>University of Turin</institution>, Turin 10126,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><affiliation wicri:level="1"><nlm:aff id="aff40">Oxford Centre for Diabetes, Endocrinology and Metabolism,<institution>University of Oxford</institution>, Oxford OX3 7LJ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mueller, Christian" sort="Mueller, Christian" uniqKey="Mueller C" first="Christian" last="Mueller">Christian Mueller</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff41">Department of Psychiatry and Psychotherapy,<institution>University of Erlangen-Nuernberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Internal Medicine, University Medical Center Groningen,<institution>University of Groningen</institution>, Groningen 9700 RB,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Numans, Mattijs E" sort="Numans, Mattijs E" uniqKey="Numans M" first="Mattijs E." last="Numans">Mattijs E. Numans</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nu Ez, Alejandro" sort="Nu Ez, Alejandro" uniqKey="Nu Ez A" first="Alejandro" last="Nú Ez">Alejandro Nú Ez</name><affiliation wicri:level="1"><nlm:aff id="aff22">Comision de Investigaciones Cientificas de la Provincia de Buenos Aires-Instituto de Biología Molecular y Celular del Cáncer de Salamanca,<institution>University of Salamanca–Consejo Superior de Investigaciones Cientificas (Spain)</institution>, 37007 Salamanca,<country>Spain</country>;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R." last="Nyholt">Dale R. Nyholt</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Queensland Institute of Medical Research</institution>, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Onland Moret, Charlotte N" sort="Onland Moret, Charlotte N" uniqKey="Onland Moret C" first="Charlotte N." last="Onland-Moret">Charlotte N. Onland-Moret</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff43">Complex Genetics Section, Department of Medical Genetics–Divisie Biomedische Genetica,<institution>University Medical Center</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Pharmaceutical Biosciences,<institution>Uppsala University</institution>, Uppsala 751 24,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F." last="O'Reilly">Paul F. O'Reilly</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Palkovits, Miklos" sort="Palkovits, Miklos" uniqKey="Palkovits M" first="Miklos" last="Palkovits">Miklos Palkovits</name><affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Semmelweiss University</institution>, H-1094, Budapest,<country>Hungary</country>;</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation wicri:level="1"><nlm:aff id="aff45">EMGO Institute for Health and Care Research, Department of Psychiatry,<institution>VU University Medical Center</institution>, Amsterdam 1081 BT,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff46"><institution>University Medical Center</institution>, Groningen 9700 RB,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff47"><institution>Leiden University Medical Center</institution>, Leiden 2333 ZA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polidoro, Silvia" sort="Polidoro, Silvia" uniqKey="Polidoro S" first="Silvia" last="Polidoro">Silvia Polidoro</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Institute for Scientific Interchange</institution>, Turin 10133,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation wicri:level="1"><nlm:aff id="aff48"><institution>National Institute for Health and Welfare</institution>, FI-90101, Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="1"><nlm:aff id="aff40">Oxford Centre for Diabetes, Endocrinology and Metabolism,<institution>University of Oxford</institution>, Oxford OX3 7LJ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff49">Wellcome Trust Centre for Human Genetics,<institution>University of Oxford</institution>, Oxford OX3 7BN,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ricceri, Fulvio" sort="Ricceri, Fulvio" uniqKey="Ricceri F" first="Fulvio" last="Ricceri">Fulvio Ricceri</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Institute for Scientific Interchange</institution>, Turin 10133,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Santos, Eugenio" sort="Santos, Eugenio" uniqKey="Santos E" first="Eugenio" last="Santos">Eugenio Santos</name><affiliation wicri:level="1"><nlm:aff id="aff22">Comision de Investigaciones Cientificas de la Provincia de Buenos Aires-Instituto de Biología Molecular y Celular del Cáncer de Salamanca,<institution>University of Salamanca–Consejo Superior de Investigaciones Cientificas (Spain)</institution>, 37007 Salamanca,<country>Spain</country>;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><affiliation wicri:level="1"><nlm:aff id="aff45">EMGO Institute for Health and Care Research, Department of Psychiatry,<institution>VU University Medical Center</institution>, Amsterdam 1081 BT,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="aff38">Department of Twin Research and Genetic Epidemiology,<institution>King's College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff50">Wellcome Trust Sanger Institute,<institution>Wellcome Trust Genome Campus</institution>, Hinxton CB10 1SA,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Song, Kijoung" sort="Song, Kijoung" uniqKey="Song K" first="Kijoung" last="Song">Kijoung Song</name><affiliation wicri:level="2"><nlm:aff id="aff51">Genetics Division, Research and Development,<institution>GlaxoSmithKline</institution>, King of Prussia, PA 19406;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation wicri:level="1"><nlm:aff id="aff52">Department of Medicine,<institution>University of Leipzig</institution>, 04103 Leipzig,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff53">Leipzig Research Centre for Modern Diseases (LIFE),<institution>University of Leipzig</institution>, 04103 Leipzig,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Surakk, Ida" sort="Surakk, Ida" uniqKey="Surakk I" first="Ida" last="Surakk">Ida Surakk</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Institute for Molecular Medicine</institution>, FI-00014, Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff54">Public Health Genomics,<institution>National Institute for Health and Welfare</institution>, FI-00271, Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thorgeirsson, Thorgeir E" sort="Thorgeirsson, Thorgeir E" uniqKey="Thorgeirsson T" first="Thorgeir E." last="Thorgeirsson">Thorgeir E. Thorgeirsson</name><affiliation wicri:level="1"><nlm:aff id="aff26">deCODE genetics, Faculty of Medicine,<institution>Reykjavik and University of Iceland</institution>, Reykjavik IS 101,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="aff26">deCODE genetics, Faculty of Medicine,<institution>Reykjavik and University of Iceland</institution>, Reykjavik IS 101,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Troakes, Claire" sort="Troakes, Claire" uniqKey="Troakes C" first="Claire" last="Troakes">Claire Troakes</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry,<institution>King's College</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tyrfingsson, Thorarinn" sort="Tyrfingsson, Thorarinn" uniqKey="Tyrfingsson T" first="Thorarinn" last="Tyrfingsson">Thorarinn Tyrfingsson</name><affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Vogur Samtök áhugafólks um áfengis Addiction Treatment Center</institution>, Reykjavik 112,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation wicri:level="1"><nlm:aff id="aff52">Department of Medicine,<institution>University of Leipzig</institution>, 04103 Leipzig,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff56">University of Leipzig,<institution>Coordination Centre for Clinical Trials</institution>, 04317 Leipzig,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uiterwaal, Cuno S" sort="Uiterwaal, Cuno S" uniqKey="Uiterwaal C" first="Cuno S." last="Uiterwaal">Cuno S. Uiterwaal</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="aff57">Department of Internal Medicine,<institution>Erasmus University Medical Center</institution>, Rotterdam 3015 CE,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, Groningen 9700 RB,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T." last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation wicri:level="1"><nlm:aff id="aff12">Julius Center for Health Sciences and Primary Care,<institution>University Medical Center Utrecht</institution>, Utrecht 3508 GA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Staehlin, Oliver" sort="Staehlin, Oliver" uniqKey="Staehlin O" first="Oliver" last="Staehlin">Oliver Staehlin</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Psychopharmacology,<institution>Central Institute of Mental Health</institution>, 68159 Mannheim,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vogelzangs, Nicole" sort="Vogelzangs, Nicole" uniqKey="Vogelzangs N" first="Nicole" last="Vogelzangs">Nicole Vogelzangs</name><affiliation wicri:level="1"><nlm:aff id="aff45">EMGO Institute for Health and Care Research, Department of Psychiatry,<institution>VU University Medical Center</institution>, Amsterdam 1081 BT,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="1"><nlm:aff id="aff58">Department of Medicine,<institution>Centre Hospitalier Universitaire Vaudois University Hospital</institution>, CH-1011 Lausanne,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gerard" last="Waeber">Gerard Waeber</name><affiliation wicri:level="1"><nlm:aff id="aff58">Department of Medicine,<institution>Centre Hospitalier Universitaire Vaudois University Hospital</institution>, CH-1011 Lausanne,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="aff37"><institution>Medical Research Council Epidemiology Unit–Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom;</institution></nlm:aff></affiliation></author><author><name sortKey="Waterworth, Dawn M" sort="Waterworth, Dawn M" uniqKey="Waterworth D" first="Dawn M." last="Waterworth">Dawn M. Waterworth</name><affiliation wicri:level="2"><nlm:aff id="aff51">Genetics Division, Research and Development,<institution>GlaxoSmithKline</institution>, King of Prussia, PA 19406;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Queensland Institute of Medical Research</institution>, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wichmann, Erich H" sort="Wichmann, Erich H" uniqKey="Wichmann E" first="Erich H." last="Wichmann">Erich H. Wichmann</name><affiliation wicri:level="1"><nlm:aff id="aff35">Institute of Epidemiology, Helmholtz Zentrum,<institution>German Research Center for Environmental Health</institution>, D-85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff59">Institute of Medical Informatics, Biometry and Epidemiology,<institution>Ludwig Maximilians University</institution>, D-80336 Munich,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff60"><institution>Klinikum Grosshadern</institution>, D-81377 Munich,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Biological Psychology,<institution>Vrije Universiteit and VU Medical Center</institution>, Amsterdam 1081 HV,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Witteman, Jacqueline C" sort="Witteman, Jacqueline C" uniqKey="Witteman J" first="Jacqueline C." last="Witteman">Jacqueline C. Witteman</name><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Epidemiology,<institution>Erasmus University Medical Center</institution>, Rotterdam 3015 GE,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yuan, Xin" sort="Yuan, Xin" uniqKey="Yuan X" first="Xin" last="Yuan">Xin Yuan</name><affiliation wicri:level="2"><nlm:aff id="aff51">Genetics Division, Research and Development,<institution>GlaxoSmithKline</institution>, King of Prussia, PA 19406;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Zhai, Guangju" sort="Zhai, Guangju" uniqKey="Zhai G" first="Guangju" last="Zhai">Guangju Zhai</name><affiliation wicri:level="1"><nlm:aff id="aff38">Department of Twin Research and Genetic Epidemiology,<institution>King's College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jing H" sort="Zhao, Jing H" uniqKey="Zhao J" first="Jing H." last="Zhao">Jing H. Zhao</name><affiliation><nlm:aff id="aff37"><institution>Medical Research Council Epidemiology Unit–Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom;</institution></nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Queensland Institute of Medical Research</institution>, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Biotechnology, Institute of Molecular and Cell Biology, Faculty of Science and Technology,<institution>University of Tartu</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Estonian Genome Project of University of Tartu</institution>, Tartu 50410,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Estonian Biocentre</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Doering, Angela" sort="Doering, Angela" uniqKey="Doering A" first="Angela" last="Doering">Angela Doering</name><affiliation wicri:level="1"><nlm:aff id="aff35">Institute of Epidemiology, Helmholtz Zentrum,<institution>German Research Center for Environmental Health</institution>, D-85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="aff38">Department of Twin Research and Genetic Epidemiology,<institution>King's College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loos, Ruth J" sort="Loos, Ruth J" uniqKey="Loos R" first="Ruth J." last="Loos">Ruth J. Loos</name><affiliation><nlm:aff id="aff37"><institution>Medical Research Council Epidemiology Unit–Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom;</institution></nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Biological Psychology,<institution>Vrije Universiteit and VU Medical Center</institution>, Amsterdam 1081 HV,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mooser, Vincent" sort="Mooser, Vincent" uniqKey="Mooser V" first="Vincent" last="Mooser">Vincent Mooser</name><affiliation wicri:level="2"><nlm:aff id="aff51">Genetics Division, Research and Development,<institution>GlaxoSmithKline</institution>, King of Prussia, PA 19406;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation wicri:level="1"><nlm:aff id="aff50">Wellcome Trust Sanger Institute,<institution>Wellcome Trust Genome Campus</institution>, Hinxton CB10 1SA,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="aff62">Institute for Molecular Medicine Finland (FIMM), Nordic European Molecular Biology Laboratory Partnership for Molecular Medicine, Biomedicum Helsinki 2U,<institution>University of Helsinki and National Institute for Health and Welfare, FI-00014, Helsinki, Finland</institution>;</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="aff26">deCODE genetics, Faculty of Medicine,<institution>Reykjavik and University of Iceland</institution>, Reykjavik IS 101,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="aff7">Genetic Epidemiology Unit, Department of Epidemiology and Clinical Genetics,<institution>Erasmus University Medical Centre</institution>, Rotterdam 3000CA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Institute for Scientific Interchange</institution>, Turin 10133,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sommer, Wolfgang H" sort="Sommer, Wolfgang H" uniqKey="Sommer W" first="Wolfgang H." last="Sommer">Wolfgang H. Sommer</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Psychopharmacology,<institution>Central Institute of Mental Health</institution>, 68159 Mannheim,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation wicri:level="1"><nlm:aff id="aff63">Faculty of Medicine, National Heart and Lung Institute, Cardiovascular Science, Hammersmith Hospital, Hammersmith Campus,<institution>Imperial College</institution> London, London W12 0NN,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spanagel, Rainer" sort="Spanagel, Rainer" uniqKey="Spanagel R" first="Rainer" last="Spanagel">Rainer Spanagel</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Psychopharmacology,<institution>Central Institute of Mental Health</institution>, 68159 Mannheim,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heberlein, Ulrike A" sort="Heberlein, Ulrike A" uniqKey="Heberlein U" first="Ulrike A." last="Heberlein">Ulrike A. Heberlein</name><affiliation wicri:level="2"><nlm:aff id="aff5">Ernest Gallo Clinic and Research Center,<institution>University of California at San Francisco</institution>, Emeryville, CA 94608;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>, Emeryville</wicri:cityArea></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff48"><institution>National Institute for Health and Welfare</institution>, FI-90101, Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="aff64">Institute of Health Sciences,<institution>University of Oulu, FI-90014, Oulu, Finland</institution>;</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff65">Biocenter Oulu,<institution>University of Oulu</institution>, FI-90014, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>, FI-90014, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff66">Medical Research Council-Health Protection Agency Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College</institution> London, London W2 1PG,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in <italic>autism susceptibility candidate 2</italic> gene (<italic>AUTS2</italic>) was associated with alcohol consumption at genome-wide significance (<italic>P</italic> = 4 × 10<sup>−8</sup> to <italic>P</italic> = 4 × 10<sup>−9</sup>). We found a genotype-specific expression of <italic>AUTS2</italic> in 96 human prefrontal cortex samples (<italic>P =</italic> 0.026) and significant (<italic>P</italic> < 0.017) differences in expression of <italic>AUTS2</italic> in whole-brain extracts of mice selected for differences in voluntary alcohol consumption. Down-regulation of an <italic>AUTS2</italic> homolog caused reduced alcohol sensitivity in <italic>Drosophila</italic> (<italic>P</italic> < 0.001). Our finding of a regulator of alcohol consumption adds knowledge to our understanding of genetic mechanisms influencing alcohol drinking behavior.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>Estonie</li><li>Finlande</li><li>France</li><li>Hongrie</li><li>Islande</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>Thaïlande</li><li>États-Unis</li></country><region><li>Californie</li><li>Connecticut</li><li>Indiana</li><li>Missouri (État)</li><li>Pennsylvanie</li><li>Virginie</li></region></list><tree><noCountry><name sortKey="Beury, Delphine" sort="Beury, Delphine" uniqKey="Beury D" first="Delphine" last="Beury">Delphine Beury</name><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stéphane" last="Cauchi">Stéphane Cauchi</name><name sortKey="Cavalcanti Proenca, Christine" sort="Cavalcanti Proenca, Christine" uniqKey="Cavalcanti Proenca C" first="Christine" last="Cavalcanti-Proença">Christine Cavalcanti-Proença</name><name sortKey="Lobbens, Stephane" sort="Lobbens, Stephane" uniqKey="Lobbens S" first="Stéphane" last="Lobbens">Stéphane Lobbens</name><name sortKey="Loos, Ruth J" sort="Loos, Ruth J" uniqKey="Loos R" first="Ruth J." last="Loos">Ruth J. Loos</name><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><name sortKey="Zhao, Jing H" sort="Zhao, Jing H" uniqKey="Zhao J" first="Jing H." last="Zhao">Jing H. Zhao</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name></noRegion><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C." last="Chambers">John C. Chambers</name><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><name sortKey="Clarke, Toni Kim" sort="Clarke, Toni Kim" uniqKey="Clarke T" first="Toni-Kim" last="Clarke">Toni-Kim Clarke</name><name sortKey="Coin, Lachlan J" sort="Coin, Lachlan J" uniqKey="Coin L" first="Lachlan J." last="Coin">Lachlan J. Coin</name><name sortKey="Desrivieres, Sylvane" sort="Desrivieres, Sylvane" uniqKey="Desrivieres S" first="Sylvane" last="Desrivières">Sylvane Desrivières</name><name sortKey="Ducci, Francesca" sort="Ducci, Francesca" uniqKey="Ducci F" first="Francesca" last="Ducci">Francesca Ducci</name><name sortKey="Easton, Alanna" sort="Easton, Alanna" uniqKey="Easton A" first="Alanna" last="Easton">Alanna Easton</name><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Khan, Anokhi A" sort="Khan, Anokhi A" uniqKey="Khan A" first="Anokhi A." last="Khan">Anokhi A. Khan</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><name sortKey="Lourdusamy, Anbarasu" sort="Lourdusamy, Anbarasu" uniqKey="Lourdusamy A" first="Anbarasu" last="Lourdusamy">Anbarasu Lourdusamy</name><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><name sortKey="Mueller, Christian" sort="Mueller, Christian" uniqKey="Mueller C" first="Christian" last="Mueller">Christian Mueller</name><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F." last="O'Reilly">Paul F. O'Reilly</name><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><name sortKey="Stacey, David" sort="Stacey, David" uniqKey="Stacey D" first="David" last="Stacey">David Stacey</name><name sortKey="Troakes, Claire" sort="Troakes, Claire" uniqKey="Troakes C" first="Claire" last="Troakes">Claire Troakes</name><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><name sortKey="Zhai, Guangju" sort="Zhai, Guangju" uniqKey="Zhai G" first="Guangju" last="Zhai">Guangju Zhai</name><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name></country><country name="Thaïlande"><noRegion><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name></noRegion></country><country name="États-Unis"><region name="Californie"><name sortKey="Berger, Karen H" sort="Berger, Karen H" uniqKey="Berger K" first="Karen H." last="Berger">Karen H. Berger</name></region><name sortKey="Aliev, Fazil A" sort="Aliev, Fazil A" uniqKey="Aliev F" first="Fazil A." last="Aliev">Fazil A. Aliev</name><name sortKey="De Geus, Eco J" sort="De Geus, Eco J" uniqKey="De Geus E" first="Eco J." last="De Geus">Eco J. De Geus</name><name sortKey="Dick, Danielle" sort="Dick, Danielle" uniqKey="Dick D" first="Danielle" last="Dick">Danielle Dick</name><name sortKey="Edenberg, Howard J" sort="Edenberg, Howard J" uniqKey="Edenberg H" first="Howard J." last="Edenberg">Howard J. Edenberg</name><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B." last="Freimer">Nelson B. Freimer</name><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><name sortKey="Heberlein, Ulrike A" sort="Heberlein, Ulrike A" uniqKey="Heberlein U" first="Ulrike A." last="Heberlein">Ulrike A. Heberlein</name><name sortKey="Hesselbrock, Victor" sort="Hesselbrock, Victor" uniqKey="Hesselbrock V" first="Victor" last="Hesselbrock">Victor Hesselbrock</name><name sortKey="Mooser, Vincent" sort="Mooser, Vincent" uniqKey="Mooser V" first="Vincent" last="Mooser">Vincent Mooser</name><name sortKey="Song, Kijoung" sort="Song, Kijoung" uniqKey="Song K" first="Kijoung" last="Song">Kijoung Song</name><name sortKey="Waterworth, Dawn M" sort="Waterworth, Dawn M" uniqKey="Waterworth D" first="Dawn M." last="Waterworth">Dawn M. Waterworth</name><name sortKey="Yuan, Xin" sort="Yuan, Xin" uniqKey="Yuan X" first="Xin" last="Yuan">Xin Yuan</name></country><country name="Pays-Bas"><noRegion><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name></noRegion><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><name sortKey="Bakker, Stephan J" sort="Bakker, Stephan J" uniqKey="Bakker S" first="Stephan J." last="Bakker">Stephan J. Bakker</name><name sortKey="Beulens, Joline W" sort="Beulens, Joline W" uniqKey="Beulens J" first="Joline W." last="Beulens">Joline W. Beulens</name><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><name sortKey="Bots, Michiel L" sort="Bots, Michiel L" uniqKey="Bots M" first="Michiel L." last="Bots">Michiel L. Bots</name><name sortKey="Breetvelt, Elemi J" sort="Breetvelt, Elemi J" uniqKey="Breetvelt E" first="Elemi J." last="Breetvelt">Elemi J. Breetvelt</name><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A." last="De Boer">Rudolf A. De Boer</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><name sortKey="Numans, Mattijs E" sort="Numans, Mattijs E" uniqKey="Numans M" first="Mattijs E." last="Numans">Mattijs E. Numans</name><name sortKey="Onland Moret, Charlotte N" sort="Onland Moret, Charlotte N" uniqKey="Onland Moret C" first="Charlotte N." last="Onland-Moret">Charlotte N. Onland-Moret</name><name sortKey="Onland Moret, Charlotte N" sort="Onland Moret, Charlotte N" uniqKey="Onland Moret C" first="Charlotte N." last="Onland-Moret">Charlotte N. Onland-Moret</name><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><name sortKey="Uiterwaal, Cuno S" sort="Uiterwaal, Cuno S" uniqKey="Uiterwaal C" first="Cuno S." last="Uiterwaal">Cuno S. Uiterwaal</name><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T." last="Van Der Schouw">Yvonne T. Van Der Schouw</name><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><name sortKey="Vogelzangs, Nicole" sort="Vogelzangs, Nicole" uniqKey="Vogelzangs N" first="Nicole" last="Vogelzangs">Nicole Vogelzangs</name><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><name sortKey="Witteman, Jacqueline C" sort="Witteman, Jacqueline C" uniqKey="Witteman J" first="Jacqueline C." last="Witteman">Jacqueline C. Witteman</name></country><country name="Suède"><noRegion><name sortKey="Bakalkin, Georgy" sort="Bakalkin, Georgy" uniqKey="Bakalkin G" first="Georgy" last="Bakalkin">Georgy Bakalkin</name></noRegion><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name></country><country name="France"><noRegion><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name></noRegion><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><name sortKey="Girault, Jean Antoine" sort="Girault, Jean Antoine" uniqKey="Girault J" first="Jean-Antoine" last="Girault">Jean-Antoine Girault</name><name sortKey="Maroteaux, Matthieu" sort="Maroteaux, Matthieu" uniqKey="Maroteaux M" first="Matthieu" last="Maroteaux">Matthieu Maroteaux</name></country><country name="Allemagne"><noRegion><name sortKey="Bilbao, Ainhoa" sort="Bilbao, Ainhoa" uniqKey="Bilbao A" first="Ainhoa" last="Bilbao">Ainhoa Bilbao</name></noRegion><name sortKey="Dahmen, Norbert" sort="Dahmen, Norbert" uniqKey="Dahmen N" first="Norbert" last="Dahmen">Norbert Dahmen</name><name sortKey="Doering, Angela" sort="Doering, Angela" uniqKey="Doering A" first="Angela" last="Doering">Angela Doering</name><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E." last="Grobbee">Diederick E. Grobbee</name><name sortKey="Kuehnel, Brigitte" sort="Kuehnel, Brigitte" uniqKey="Kuehnel B" first="Brigitte" last="Kuehnel">Brigitte Kuehnel</name><name sortKey="Mueller, Christian" sort="Mueller, Christian" uniqKey="Mueller C" first="Christian" last="Mueller">Christian Mueller</name><name sortKey="Sommer, Wolfgang H" sort="Sommer, Wolfgang H" uniqKey="Sommer W" first="Wolfgang H." last="Sommer">Wolfgang H. 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Wichmann</name></country><country name="Estonie"><noRegion><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name></noRegion><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name></country><country name="Espagne"><noRegion><name sortKey="Fernandez Medarde, Alberto" sort="Fernandez Medarde, Alberto" uniqKey="Fernandez Medarde A" first="Alberto" last="Fernández-Medarde">Alberto Fernández-Medarde</name></noRegion><name sortKey="Nu Ez, Alejandro" sort="Nu Ez, Alejandro" uniqKey="Nu Ez A" first="Alejandro" last="Nú Ez">Alejandro Nú Ez</name><name sortKey="Santos, Eugenio" sort="Santos, Eugenio" uniqKey="Santos E" first="Eugenio" last="Santos">Eugenio Santos</name></country><country name="Italie"><noRegion><name sortKey="Guarrera, Simonetta" sort="Guarrera, Simonetta" uniqKey="Guarrera S" first="Simonetta" last="Guarrera">Simonetta Guarrera</name></noRegion><name sortKey="Matullo, Giuseppe" sort="Matullo, Giuseppe" uniqKey="Matullo G" first="Giuseppe" last="Matullo">Giuseppe Matullo</name><name sortKey="Polidoro, Silvia" sort="Polidoro, Silvia" uniqKey="Polidoro S" first="Silvia" last="Polidoro">Silvia Polidoro</name><name sortKey="Ricceri, Fulvio" sort="Ricceri, Fulvio" uniqKey="Ricceri F" first="Fulvio" last="Ricceri">Fulvio Ricceri</name><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></country><country name="Islande"><noRegion><name sortKey="Gudbjartsson, Daniel F" sort="Gudbjartsson, Daniel F" uniqKey="Gudbjartsson D" first="Daniel F." last="Gudbjartsson">Daniel F. Gudbjartsson</name></noRegion><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><name sortKey="Thorgeirsson, Thorgeir E" sort="Thorgeirsson, Thorgeir E" uniqKey="Thorgeirsson T" first="Thorgeir E." last="Thorgeirsson">Thorgeir E. Thorgeirsson</name><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><name sortKey="Tyrfingsson, Thorarinn" sort="Tyrfingsson, Thorarinn" uniqKey="Tyrfingsson T" first="Thorarinn" last="Tyrfingsson">Thorarinn Tyrfingsson</name></country><country name="Finlande"><noRegion><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name></noRegion><name sortKey="Isohanni, Matti K" sort="Isohanni, Matti K" uniqKey="Isohanni M" first="Matti K." last="Isohanni">Matti K. 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Nyholt</name></noRegion><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name></country><country name="Hongrie"><noRegion><name sortKey="Palkovits, Miklos" sort="Palkovits, Miklos" uniqKey="Palkovits M" first="Miklos" last="Palkovits">Miklos Palkovits</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name></noRegion><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gerard" last="Waeber">Gerard Waeber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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